We apply genomic and cancer biology approaches to define the molecular taxonomy and tumor microenvironment of skull base tumors. In particular, we seek to understand tumor cell evolution and their acquisition of resistance to innate immune mechanisms as well as administered treatments. Collectively, we hope to define molecular markers with diagnostic and prognostic potential to track brain tumors across time and to develop improved therapeutic options.
Safe skull base surgery is predicated on detailed knowledge of the relevant anatomy. We aim to apply advanced imaging modalities to assess critical structures that may be encountered during the operative approach to improve preservation of neurovascular function.
Ongoing studies focus on the impact of operative technique, perioperative routine, and adjuvant therapy regimens on outcomes of meningiomas, pituitary tumors, schwannomas, brain metastases, and tumors in challenging anatomical locations, in retrospective and prospective fashion.